Triethyl phosphonoacetate is used as a flame retardant by Shanghai Solu New Materials Co., Ltd. (already in mass production) and Rukun (Shandong) New Materials Technology Co., Ltd. (under testing and amplification)
Trimethylphosphonoacetate 301
[[Triethylphosphonoacetate]][[302]]
[[Triethyl 2-fluoro-2-phosphonoacetate]] 2F302
[[Triethyl 2-chloro-2-phosphonoacetate]] 2L302
[[Triethyl 2-phosphonopropionate]] 332
Dimethyl Ethylphosphonoacetate 303
Diethyl methylphosphonoacetate 304
Dimethoxyphosphonoacetate tert-butyl ester 305
Diethoxyphosphonoacetate tert-butyl ester 306
[[diethyl cyanomethylphosphonate]] 308
Diethyl Acetone Phosphonate
[[Vinyl diethyl phosphonate]] This material is currently the most widely used

Trimethyl Phosphonoacetate (TMPA) Chemical
Formula: C5H11O5P

Molecular Weight: 182.11 g/mol
CAS Number: 5927-18-4
Appearance: Colorless liquid
Odor: Faint, ester-like odor
Solubility: Soluble in water, ethanol, and other organic solvents
Chemical Properties:

Melting Point: -42 °C (-44 °F)
Boiling Point: 210 °C (410 °F) at 10 mmHg
Density: 1.125 g/mL at 25 °C (77 °F)
Acidity: Weakly acidic

Applications
Organic synthesis: TMPA is a versatile building block used in the synthesis of various organic compounds, including:

Acrylate esters (used in paints, coatings, and adhesives)
Phosphonates (used in pharmaceuticals and flame retardants)
Heterocyclic compounds (used in pharmaceuticals and agrochemicals)
Horner-Wadsworth-Emmons reaction: TMPA serves as a reactant in this organic reaction to form carbon-carbon double bonds.

Safety Hazards:
Toxic: TMPA can be harmful if inhaled, ingested, or absorbed through the skin. It can cause irritation of the eyes, skin, and respiratory system.
Flammable: TMPA is a flammable liquid that can ignite easily.
Corrosive: TMPA can be corrosive to metals.
Dual-use concern: TMPA can be used as a precursor to the chemical warfare agent Sarin. Due to this, some countries may have restrictions on its sale and use.
Handling and Storage:

TMPA should be handled with care in a well-ventilated area using appropriate personal protective equipment (PPE), including gloves, safety glasses, and a respirator.
Store TMPA in a cool, dry place away from heat, ignition sources, and incompatible materials.
Always follow proper disposal procedures for TMPA and its containers.

Regulations:
TMPA may be subject to regulations regarding its purchase, use, and disposal depending on your location. It's important to consult the relevant authorities in your area for specific information.

Additional Information:
TMPA is a relatively reactive compound and should be handled by trained personnel familiar with its properties and safety hazards.
Disclaimer: This information is for educational purposes only and should not be construed as advice for handling or using Trimethyl Phosphonoacetate. Always consult with a qualified professional for handling and safety procedures.

Trimethyl Phosphonoacetate (TMPA) has two main application areas: organic synthesis and the Horner-Wadsworth-Emmons reaction. However, it's important to note that TMPA is a controlled substance in some countries due to its potential use as a precursor in the production of the chemical warfare agent Sarin.

Here's a breakdown of its legitimate applications

Organic Synthesis
TMPA is a valuable building block used in the synthesis of various organic compounds, including

Acrylate Esters: These esters are widely used in the production of paints, coatings, and adhesives. TMPA helps create the chemical structure needed for these materials.

Phosphonates: This class of compounds has diverse applications. Some phosphonates are used in pharmaceuticals as drugs or drug intermediates. Others find use as flame retardants in various materials. TMPA serves as a starting material for creating the phosphonate structure.

Heterocyclic Compounds: These are organic compounds with a ring structure containing at least one atom other than carbon. Heterocyclic compounds have a wide range of applications, including in pharmaceuticals and agrochemicals. TMPA can be a starting material for some heterocyclic syntheses.

Horner-Wadsworth-Emmons Reaction

This organic reaction is a powerful tool for creating carbon-carbon double bonds in molecules. TMPA acts as a reactant in this reaction, allowing chemists to efficiently introduce these double bonds into various organic compounds. These double bonds are crucial for the functionality of many organic molecules.